Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/152143
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells |
Autor: | González-Sarrías, Antonio CSIC ORCID; Núñez-Sánchez, María Ángeles; Tomás Barberán, Francisco CSIC ORCID ; Espín de Gea, Juan Carlos CSIC ORCID | Palabras clave: | Ellagic acid Gallic acid Neuroprotective effects Phenolic acids Polyphenol Urolithins |
Fecha de publicación: | 14-nov-2016 | Editor: | American Chemical Society | Citación: | Journal of agricultural and food chemistry 65: 752-758 (2017) | Resumen: | Oxidative stress is involved in cell death in neurodegenerative diseases. Dietary polyphenols can exert health benefits, but their direct effects on neuronal cells are debatable because most phenolics are metabolized and do not reach the brain as they occur in the dietary sources. Herein, we evaluate the effects of a panel of bioavailable polyphenols and derived metabolites at physiologically relevant conditions against H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells. Among the 19 metabolites tested, 3,4-dihydroxyphenylpropionic acid, 3,4-dihydroxyphenylacetic acid, gallic acid, ellagic acid, and urolithins prevented neuronal apoptosis via attenuation of ROS levels, increased REDOX activity, and decreased oxidative stress-induced apoptosis by preventing the caspase-3 activation via the mitochondrial apoptotic pathway in SH-SY5Y cells. This suggests that dietary sources containing the polyphenol precursors of these molecules such as cocoa, berries, walnuts, and tea could be potential functional foods to reduce oxidative stress associated with the onset and progress of neurodegenerative diseases. | Versión del editor: | http://doi.org/10.1021/acs.jafc.6b04538 | URI: | http://hdl.handle.net/10261/152143 | DOI: | 10.1021/acs.jafc.6b04538 | ISSN: | 0021-8561 | E-ISSN: | 1520-5118 |
Aparece en las colecciones: | (CEBAS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2017 Gonzalez-Sarrias Microbiota metabolites neuroprotective .JAFC.pdf | 961,35 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
124
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
118
checked on 27-feb-2024
Page view(s)
305
checked on 18-abr-2024
Download(s)
398
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.