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Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

AutorManach, Claudine; Milenkovic, Dragan; Wiele, Tom Van de; Rodríguez-Mateos, Ana; Roos, Baukje de; García-Conesa, María Teresa ; Landberg, Rikard; Gibney, Eileen R.; Heinonen, Marina; Tomás Barberán, Francisco; Morand, Christine
Palabras clavePlant food bioactives
Inter-individual variation
Bioavailability and metabolism
Biological responsiveness
Cardiometabolic health
Fecha de publicaciónjun-2017
EditorJohn Wiley & Sons
CitaciónMolecular Nutrition and Food Research 61(6): 1600557 (2017)
ResumenBioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.
Versión del editorhttp://doi.org/10.1002/mnfr.201600557
URIhttp://hdl.handle.net/10261/152137
DOI10.1002/mnfr.201600557
ISSN1613-4125
E-ISSN1613-4133
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