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Título: | Role of redoximiRs in fibrogenesis |
Autor: | Fierro-Fernández, Marta CSIC; Miguel, Verónica CSIC ORCID; Lamas Peláez, Santiago CSIC ORCID | Palabras clave: | Fibrosis Oxidative stress MicroRNAs |
Fecha de publicación: | 19-nov-2015 | Editor: | Elsevier | Citación: | Redox Biology 7: 58- 67 (2016) | Resumen: | Fibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed >fibromiRs>. Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed >redoximiRs>. Here, we review the current knowledge of mechanisms by which >redoximiRs> regulate fibrogenesis. This new set of miRNAs may be called >redoxifibromiRs>. | URI: | http://hdl.handle.net/10261/152106 | DOI: | 10.1016/j.redox.2015.11.006 | Identificadores: | doi: 10.1016/j.redox.2015.11.006 issn: 2213-2317 |
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LamasS_RoleOfRedoximiRsInFibrogenesis.pdf | 1,18 MB | Adobe PDF | Visualizar/Abrir |
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