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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/152106
Título

Role of redoximiRs in fibrogenesis

AutorFierro-Fernández, Marta ; Miguel, Verónica ; Lamas Peláez, Santiago
Palabras claveFibrosis
Oxidative stress
MicroRNAs
Fecha de publicación19-nov-2015
EditorElsevier
CitaciónRedox Biology 7: 58- 67 (2016)
ResumenFibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed >fibromiRs>. Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed >redoximiRs>. Here, we review the current knowledge of mechanisms by which >redoximiRs> regulate fibrogenesis. This new set of miRNAs may be called >redoxifibromiRs>.
URIhttp://hdl.handle.net/10261/152106
DOI10.1016/j.redox.2015.11.006
Identificadoresdoi: 10.1016/j.redox.2015.11.006
issn: 2213-2317
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