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Title

Role of redoximiRs in fibrogenesis

AuthorsFierro-Fernández, Marta CSIC; Miguel, Verónica CSIC ORCID; Lamas Peláez, Santiago CSIC ORCID
KeywordsFibrosis
Oxidative stress
MicroRNAs
Issue Date19-Nov-2015
PublisherElsevier
CitationRedox Biology 7: 58- 67 (2016)
AbstractFibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed >fibromiRs>. Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed >redoximiRs>. Here, we review the current knowledge of mechanisms by which >redoximiRs> regulate fibrogenesis. This new set of miRNAs may be called >redoxifibromiRs>.
URIhttp://hdl.handle.net/10261/152106
DOI10.1016/j.redox.2015.11.006
Identifiersdoi: 10.1016/j.redox.2015.11.006
issn: 2213-2317
Appears in Collections:(CBM) Artículos

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