1. DIGITAL.CSIC
  2. Recursos Naturales
  3. Instituto de Biología Evolutiva (IBE)
  4. (IBE) Artículos
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/152048
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE

Comparte tu historia
de Acceso Abierto
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorMartínez-Cruz, Begoñaes_ES
dc.contributor.authorMendizabal, Isabeles_ES
dc.contributor.authorBertranpetit, Jaumees_ES
dc.contributor.authorComas, Davides_ES
dc.contributor.authorGenographic Consortiumes_ES
dc.date.accessioned2017-06-27T07:00:44Z-
dc.date.available2017-06-27T07:00:44Z-
dc.date.issued2016-
dc.identifier.citationEuropean Journal of Human Genetics 24: 937-943 (2016)es_ES
dc.identifier.issn1018-4813-
dc.identifier.urihttp://hdl.handle.net/10261/152048-
dc.descriptionMartínez-Cruz, Begoña et al.es_ES
dc.description.abstractThe Roma, also known as ‘Gypsies’, represent the largest and the most widespread ethnic minority of Europe. There is increasing evidence, based on linguistic, anthropological and genetic data, to suggest that they originated from the Indian subcontinent, with subsequent bottlenecks and undetermined gene flow from/to hosting populations during their diaspora. Further support comes from the presence of Indian uniparentally inherited lineages, such as mitochondrial DNA M and Y-chromosome H haplogroups, in a significant number of Roma individuals. However, the limited resolution of most genetic studies so far, together with the restriction of the samples used, have prevented the detection of other non-Indian founder lineages that might have been present in the proto-Roma population. We performed a high-resolution study of the uniparental genomes of 753 Roma and 984 non-Roma hosting European individuals. Roma groups show lower genetic diversity and high heterogeneity compared with non-Roma samples as a result of lower effective population size and extensive drift, consistent with a series of bottlenecks during their diaspora. We found a set of founder lineages, present in the Roma and virtually absent in the non-Roma, for the maternal (H7, J1b3, J1c1, M18, M35b, M5a1, U3, and X2d) and paternal (I-P259, J-M92, and J-M67) genomes. This lineage classification allows us to identify extensive gene flow from non-Roma to Roma groups, whereas the opposite pattern, although not negligible, is substantially lower (up to 6.3%). Finally, the exact haplotype matching analysis of both uniparental lineages consistently points to a Northwestern origin of the proto-Roma population within the Indian subcontinent.es_ES
dc.description.sponsorshipThis study was partly supported by the Spanish Ministerio de Economía y Competitividad Grant CGL2013-44351-P.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2013-44351-Pes_ES
dc.rightsclosedAccesses_ES
dc.titleOrigins, admixture and founder lineages in European Romaes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/ejhg.2015.201-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1038/ejhg.2015.201es_ES
dc.identifier.e-issn1476-5438-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.pmid26374132-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

PubMed Central
Citations

18
checked on 20-mar-2024

SCOPUSTM   
Citations

41
checked on 16-abr-2024

WEB OF SCIENCETM
Citations

38
checked on 27-feb-2024

Page view(s)

304
checked on 19-abr-2024

Download(s)

139
checked on 19-abr-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.