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Title

No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity

AuthorsGarcia-Etxebarria, Koldo; Bonet, Núria; Garcia-Garcerà, Marc ; Calafell, Francesc
Issue Date17-Sep-2015
PublisherPublic Library of Science
CitationPLoS ONE 10(9): e0135983 (2015)
AbstractWhile most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.
DescriptionGarcia-Etxebarria, Koldo et al.
Publisher version (URL)https://doi.org/10.1371/journal.pone.0135983
URIhttp://hdl.handle.net/10261/152030
DOIhttp://dx.doi.org/10.1371/journal.pone.0135983
ISSN1932-6203
Appears in Collections:(IBE) Artículos
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