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http://hdl.handle.net/10261/151959
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dc.contributor.author | Fraga, Braulio M. | - |
dc.contributor.author | Guillermo, Ricardo | - |
dc.contributor.author | Hernández, Melchor G. | - |
dc.contributor.author | Chamy, María C. | - |
dc.contributor.author | Garbarino, Juan A. | - |
dc.date.accessioned | 2017-06-23T12:42:38Z | - |
dc.date.available | 2017-06-23T12:42:38Z | - |
dc.date.issued | 2012-02-09 | - |
dc.identifier | doi: 10.3390/molecules17021744 | - |
dc.identifier.citation | Molecules 17 (2): 1744-1750 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/151959 | - |
dc.description.abstract | The biotransformation of 13a,17-dihydroxystemodane (<strong>3</strong>) with the fungus <em>Cephalosporium aphidicola </em>afforded 13a,17,18-trihydroxystemodane (<strong>4</strong>), 3b,13a,17-tri-hydroxystemodane (<strong>5</strong>), 13a,17-dihydroxy-stemodan-18-oic acid (<strong>6</strong>), 3b,11β,13a,17-tetra-hydroxystemodane (<strong>7</strong>), 11β,13a,17,18-tetrahydroxystemodane (<strong>8</strong>) and 3b,13a,17,18-tetra-hydroxystemodane (<strong>9</strong>). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (<strong>2</strong>) is hydroxylated at this carbon. However, the C-3(b) and C-11(b) hydroxylations seem to indicate a xenobiotic biotransformation. | - |
dc.description.sponsorship | This work has been supported by grant CTQ2009-14629-C02-01, Ministerio de Ciencia e Innovación (MICINN), Spain. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation.isversionof | Publisher's version | - |
dc.title | The Incubation of 13a,17-Dihydroxystemodane with Cephalosporium aphidicola | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/molecules17021744 | - |
dc.relation.publisherversion | https://doi.org/10.3390/molecules17021744 | - |
dc.date.updated | 2017-06-23T12:42:38Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/3.0 | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.pmid | 22322449 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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molecules-17-01744.pdf | 186,77 kB | Adobe PDF | Visualizar/Abrir |
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