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From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

AutorCatalina, Mercedes; Cot, Jaume; Borrás, Miquel; Lapuente, Joaquín de; González, Javier; Balu, Alina M.; Luque, Rafael
Fecha de publicación29-abr-2013
EditorMultidisciplinary Digital Publishing Institute
CitaciónMaterials 6 (5): 1599-1607 (2013)
ResumenThe biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix<sup>®</sup> (Heal Progress (HP): 8 ± 1.55<i> vs.</i> 2.33 ± 0.52, <i>p</i> < 0.001; Formation of Collagen (FC): 7.5 ± 1.05<i> vs.</i> 2.17 ± 0.75, <i>p</i> < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11<i> vs.</i> 5 ± 5.48, <i>p</i> < 0.05).
Versión del editorhttp://doi.org/10.3390/ma6051599
URIhttp://hdl.handle.net/10261/151958
DOI10.3390/ma6051599
Identificadoresdoi: 10.3390/ma6051599
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