From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

Abstract

The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix^® (Heal Progress (HP): 8 ± 1.55<i> vs.</i> 2.33 ± 0.52, <i>p</i> < 0.001; Formation of Collagen (FC): 7.5 ± 1.05<i> vs.</i> 2.17 ± 0.75, <i>p</i> < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11<i> vs.</i> 5 ± 5.48, <i>p</i> < 0.05).