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Molecular basis of juvenile hormone signaling

AuthorsJindra, Marek; Bellés, Xavier CSIC ORCID ; Shinoda, Tetsudo
Issue DateOct-2015
CitationCurrent Opinion in Insect Science 11: 39-46 (2015)
AbstractDespite important roles played by juvenile hormone (JH) in insects, the mechanisms underlying its action were until recently unknown. A breakthrough has been the demonstration that the bHLH-PAS protein Met is an intracellular receptor for JH. Binding of JH to Met triggers dimerization of Met with its partner protein Tai, and the resulting complex induces transcription of target genes. In addition, JH can potentiate this response by phosphorylating Met and Tai via cell membrane, second-messenger signaling. An important gene induced by the JH–Met–Tai complex is Kr-h1, which inhibits metamorphosis. Kr-h1 represses an ‘adult specifier’ gene E93. The action of this JH-activated pathway in maintaining the juvenile status is dispensable during early postembryonic development when larvae/nymphs lack competence to metamorphose.
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