Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/151863
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dc.contributor.authorIbáñez, Clara-
dc.contributor.authorCifuentes, Alejandro-
dc.contributor.authorSimó, Carolina-
dc.date.accessioned2017-06-22T12:11:01Z-
dc.date.available2017-06-22T12:11:01Z-
dc.date.issued2015-
dc.identifierdoi: 10.1016/bs.irn.2015.05.015-
dc.identifierisbn: 978-0-12-804762-0-
dc.identifier.citationOmic Studies of Neurodegenerative Disease B(Chap.4): 95-132 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/151863-
dc.description.abstractMetabolomics is gaining an important role in the investigation of neurological pathologies such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis which are characterized by the absence of reliable diagnostic markers. The magnitude of emotional, physical, and financial burden related to these three devastating pathologies can be deduced considering that nearly 20 million people worldwide suffer from these three pathologies. In this chapter, an overview of the recent advances and applications of metabolomics to investigate these major neurodegenerative diseases will be presented. Metabolomics strategies are now being developed to map potential perturbations in biochemical pathways linked to neurodegeneration. Going further, there is more and more evidence supporting the concept that these pathologies can begin years or even decades before the onset of clinical symptoms, and thus, metabolomics is also increasingly being used to discover preclinical biomarkers of these neurological diseases.-
dc.publisherElsevier-
dc.relation.ispartofseriesInternational Review of Neurobiology 122-
dc.rightsclosedAccess-
dc.subjectAlzheimer's disease-
dc.subjectNuclear magnetic resonance-
dc.subjectMass spectrometry-
dc.subjectFingerprinting-
dc.subjectAmyotrophic lateral sclerosis-
dc.subjectParkinson's disease-
dc.subjectMetabolomics-
dc.titleRecent advances and applications of metabolomics to investigate neurodegenerative diseases-
dc.typecapítulo de libro-
dc.identifier.doi10.1016/bs.irn.2015.05.015-
dc.date.updated2017-06-22T12:11:01Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.relation.csic-
item.fulltextNo Fulltext-
item.openairetypecapítulo de libro-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
Appears in Collections:(CIAL) Libros y partes de libros
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