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Title

Recent advances and applications of metabolomics to investigate neurodegenerative diseases

AuthorsIbáñez, Clara CSIC ORCID; Cifuentes, Alejandro CSIC ORCID ; Simó, Carolina CSIC ORCID
KeywordsAlzheimer's disease
Nuclear magnetic resonance
Mass spectrometry
Fingerprinting
Amyotrophic lateral sclerosis
Parkinson's disease
Metabolomics
Issue Date2015
PublisherElsevier
CitationOmic Studies of Neurodegenerative Disease B(Chap.4): 95-132 (2015)
SeriesInternational Review of Neurobiology 122
AbstractMetabolomics is gaining an important role in the investigation of neurological pathologies such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis which are characterized by the absence of reliable diagnostic markers. The magnitude of emotional, physical, and financial burden related to these three devastating pathologies can be deduced considering that nearly 20 million people worldwide suffer from these three pathologies. In this chapter, an overview of the recent advances and applications of metabolomics to investigate these major neurodegenerative diseases will be presented. Metabolomics strategies are now being developed to map potential perturbations in biochemical pathways linked to neurodegeneration. Going further, there is more and more evidence supporting the concept that these pathologies can begin years or even decades before the onset of clinical symptoms, and thus, metabolomics is also increasingly being used to discover preclinical biomarkers of these neurological diseases.
URIhttp://hdl.handle.net/10261/151863
DOI10.1016/bs.irn.2015.05.015
Identifiersdoi: 10.1016/bs.irn.2015.05.015
isbn: 978-0-12-804762-0
Appears in Collections:(CIAL) Libros y partes de libros

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