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Título

High-Throughput Proteomics Reveals the Unicellular Roots of Animal Phosphosignaling and Cell Differentiation

AutorSebé-Pedrós, Arnau ; Peña, Marcia Ivonne; Capella-Gutiérrez, Salvador; Antó, Meritxell ; Gabaldón, Toni; Ruiz-Trillo, Iñaki ; Sabidó, Eduard
Palabras claveMulticellularity
Tyrosine kinase
Signaling
Origin of metazoa
Evolution gene expression
Mass spectrometry
Proteomics
Phosphoproteomics
Capsaspora
Evolution
Fecha de publicación24-oct-2016
EditorElsevier
CitaciónDevelopmental Cell 39(2): 186-197 (2016)
ResumenCell-specific regulation of protein levels and activity is essential for the distribution of functions among multiple cell types in animals. The finding that many genes involved in these regulatory processes have a premetazoan origin raises the intriguing possibility that the mechanisms required for spatially regulated cell differentiation evolved prior to the appearance of animals. Here, we use high-throughput proteomics in Capsaspora owczarzaki, a close unicellular relative of animals, to characterize the dynamic proteome and phosphoproteome profiles of three temporally distinct cell types in this premetazoan species. We show that life-cycle transitions are linked to extensive proteome and phosphoproteome remodeling and that they affect key genes involved in animal multicellularity, such as transcription factors and tyrosine kinases. The observation of shared features between Capsaspora and metazoans indicates that elaborate and conserved phosphosignaling and proteome regulation supported temporal cell-type differentiation in the unicellular ancestor of animals.
Versión del editorhttps://doi.org/10.1016/j.devcel.2016.09.019
URIhttp://hdl.handle.net/10261/151785
DOI10.1016/j.devcel.2016.09.019
ISSN1534-5807
E-ISSN1878-1551
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