Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/151781
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus |
Autor: | López-Villodres, J.A.; Abdel-Karim, M.; Cruz, José Pedro de la; Rodríguez-Pérez, María Dolores; Reyes, J.J.; Guzmán-Moscoso, R.; Rodríguez-Gutiérrez, Guillermo CSIC ORCID ; Fernández-Bolaños Guzmán, Juan CSIC ORCID ; González-Correa, José Antonio | Palabras clave: | Platelets Inflammatory mediators Oxidative stress Vasculopathy Hydroxytyrosol Diabetes |
Fecha de publicación: | 2016 | Editor: | Elsevier | Citación: | Journal of Nutritional Biochemistry 37: 94- 100 (2016) | Resumen: | The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg day p.o.). DR had higher platelet aggregation values, higher thromboxane B, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model. | URI: | http://hdl.handle.net/10261/151781 | DOI: | 10.1016/j.jnutbio.2016.07.015 | Identificadores: | doi: 10.1016/j.jnutbio.2016.07.015 issn: 1873-4847 |
Aparece en las colecciones: | (IG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Postprint_2016_JNutBioch_V37_P94.pdf | 359,75 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
27
checked on 22-abr-2024
WEB OF SCIENCETM
Citations
22
checked on 23-feb-2024
Page view(s)
354
checked on 24-abr-2024
Download(s)
583
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons