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Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus

AutorLópez-Villodres, J.A.; Abdel-Karim, M.; De La Cruz, J.P.; Rodríguez-Pérez, M.D.; Reyes, J.J.; Guzmán-Moscoso, R.; Rodríguez-Gutiérrez, Guillermo ; Fernández-Bolaños Guzmán, Juan ; González-Correa, J.A.
Palabras clavePlatelets
Inflammatory mediators
Oxidative stress
Vasculopathy
Hydroxytyrosol
Diabetes
Fecha de publicación2016
EditorElsevier
CitaciónJournal of Nutritional Biochemistry 37: 94- 100 (2016)
ResumenThe aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg day p.o.). DR had higher platelet aggregation values, higher thromboxane B, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model.
URIhttp://hdl.handle.net/10261/151781
DOI10.1016/j.jnutbio.2016.07.015
Identificadoresdoi: 10.1016/j.jnutbio.2016.07.015
issn: 1873-4847
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