Food ingredients, cancer and foodomics

Abstract

In this work, we will present some of the latest Foodomics results obtained in our laboratory to investigate the anti-proliferative effect of food ingredients against colon cancer using in vitro assays and in vivo experiments. Whole transcriptome microarray, proteomics and MS-based non-targeted whole-metabolome approaches were employed to carry out the mentioned studies. These Foodomics strategies enabled the identification of several differentially expressed genes alone and/or linked to changed metabolic pathways that were modulated by food ingredients in cancer cells, providing new evidences at molecular level on the antiproliferative effect of food compounds.