English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/151659
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptation

AutorMondal, Mayukh ; Casals, Ferran ; Xu, Tina; Dall'Olio, Giovanni Marco; Pybus, Marc ; Netea, Mihai G.; Comas, David ; Laayouni, Hafid ; Li, Qibin; Majumder, Partha P.; Bertranpetit, Jaume
Fecha de publicación2016
EditorNature Publishing Group
CitaciónNature Genetics 48: 1066-1070 (2016)
ResumenTo shed light on the peopling of South Asia and the origins of the morphological adaptations found there, we analyzed whole-genome sequences from 10 Andamanese individuals and compared them with sequences for 60 individuals from mainland Indian populations with different ethnic histories and with publicly available data from other populations. We show that all Asian and Pacific populations share a single origin and expansion out of Africa, contradicting an earlier proposal of two independent waves of migration1, 2, 3, 4. We also show that populations from South and Southeast Asia harbor a small proportion of ancestry from an unknown extinct hominin, and this ancestry is absent from Europeans and East Asians. The footprints of adaptive selection in the genomes of the Andamanese show that the characteristic distinctive phenotypes of this population (including very short stature) do not reflect an ancient African origin but instead result from strong natural selection on genes related to human body size.
Versión del editorhttp://doi.org/10.1038/ng.3621
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.