English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/151652
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Genetic Heterogeneity in Algerian Human Populations

AuthorsBekada, Asmahan; Arauna, Laura R.; Deba, Tahria; Calafell, Francesc ; Benhamamouch, Soraya; Comas, David
Issue Date24-Sep-2015
PublisherPublic Library of Science
CitationPLoS ONE 10(9): e0138453 (2015)
AbstractThe demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.
Publisher version (URL)https://doi.org/10.1371/journal.pone.0138453
URIhttp://hdl.handle.net/10261/151652
DOI10.1371/journal.pone.0138453
ISSN1932-6203
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
journal.pone.0138453.PDF1,09 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.