Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/151552
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Domínguez-Iturza, Nuria | - |
dc.contributor.author | Calvo, Maria | - |
dc.contributor.author | Benoist, Marion | - |
dc.contributor.author | Esteban, José A. | - |
dc.contributor.author | Morales, Miguel | - |
dc.date.accessioned | 2017-06-16T10:06:38Z | - |
dc.date.available | 2017-06-16T10:06:38Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1155/2016/2819107 | - |
dc.identifier | issn: 1687-5443 | - |
dc.identifier.citation | Neural Plasticity 2016 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/151552 | - |
dc.description.abstract | Dendritic spines are mushroom-shaped protrusions of the postsynaptic membrane. Spines receive the majority of glutamatergic synaptic inputs. Their morphology, dynamics, and density have been related to synaptic plasticity and learning. The main determinant of spine shape is filamentous actin. Using FRAP, we have reexamined the actin dynamics of individual spines from pyramidal hippocampal neurons, both in cultures and in hippocampal organotypic slices. Our results indicate that, in cultures, the actin mobile fraction is independently regulated at the individual spine level, and mobile fraction values do not correlate with either age or distance from the soma. The most significant factor regulating actin mobile fraction was the presence of astrocytes in the culture substrate. Spines from neurons growing in the virtual absence of astrocytes have a more stable actin cytoskeleton, while spines from neurons growing in close contact with astrocytes show a more dynamic cytoskeleton. According to their recovery time, spines were distributed into two populations with slower and faster recovery times, while spines from slice cultures were grouped into one population. Finally, employing fast lineal acquisition protocols, we confirmed the existence of loci with high polymerization rates within the spine. | - |
dc.description.sponsorship | Spanish Ministry of the Economy and Competitiveness: BFU 2010-1753 | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1155/2016/2819107 | - |
dc.date.updated | 2017-06-16T10:06:39Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 26881098 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
EstebanJA_HippocampalDentricticSpines.pdf | 3,66 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
2
checked on 24-abr-2024
SCOPUSTM
Citations
7
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
6
checked on 23-feb-2024
Page view(s)
201
checked on 24-abr-2024
Download(s)
217
checked on 24-abr-2024