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http://hdl.handle.net/10261/151537
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dc.contributor.author | Valero, María Llanos | - |
dc.contributor.author | Sabariegos Jareño, Mª del Rosario | - |
dc.contributor.author | Cimas, Francisco J. | - |
dc.contributor.author | Perales, Celia | - |
dc.contributor.author | Domingo, Esteban | - |
dc.contributor.author | Mas-Barreiro, Antonio | - |
dc.date.accessioned | 2017-06-16T08:59:57Z | - |
dc.date.available | 2017-06-16T08:59:57Z | - |
dc.date.issued | 2016-03-28 | - |
dc.identifier | doi: 10.1128/AAC.03019-15 | - |
dc.identifier | issn: 1098-6596 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy 60: 3540- 3550 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/151537 | - |
dc.description.abstract | Hepatitis C virus (HCV) interacts with cellular components and modulates their activities for its own benefit. These interactions have been postulated as a target for antiviral treatment, and some candidate molecules are currently in clinical trials. The multifunctional cellular kinase Akt/protein kinase B (PKB) must be activated to increase the efficacy of HCV entry but is rapidly inactivated as the viral replication cycle progresses. Viral components have been postulated to be responsible for Akt/PKB inactivation, but the underlying mechanism remained elusive. In this study, we show that HCV polymerase NS5B interacts with Akt/ PKB. In the presence of transiently expressed NS5B or in replicon- or virus-infected cells, NS5B changes the cellular localization of Akt/PKB from the cytoplasm to the perinuclear region. Sequestration of Akt/PKB by NS5B could explain its exclusion from its participation in early Akt/PKB inactivation. The NS5B-Akt/PKB interaction represents a new regulatory step in the HCV infection cycle, opening possibilities for new therapeutic options. | - |
dc.description.sponsorship | Fundación Ramón Areces. CIBERehd is funded by Instituto de Salud Carlos III. Celia Perales is supported by the Miguel Servet program (Instituto de Salud Carlos III). | - |
dc.publisher | American Society for Microbiology | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Hepatitis C Virus RNA-Dependent RNA Polymerase Interacts with the Akt/PKB Kinase and Induces Its Subcellular Relocalization | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1128/AAC.03019-15 | - |
dc.date.updated | 2017-06-16T08:59:58Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.pmid | 27021315 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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DomingoE_HepatitisCVirusRNA-DependentRNA.pdf | 2,09 MB | Adobe PDF | Visualizar/Abrir |
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