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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/151517
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dc.contributor.authorSarkissian, Clio Deres_ES
dc.contributor.authorMarqués-Bonet, Tomàses_ES
dc.contributor.authorOrlando, Ludovices_ES
dc.date.accessioned2017-06-16T07:15:59Z-
dc.date.available2017-06-16T07:15:59Z-
dc.date.issued2015-10-05-
dc.identifier.citationCurrent Biology 25(19): 2577-2583 (2015)es_ES
dc.identifier.issn0960-9822-
dc.identifier.urihttp://hdl.handle.net/10261/151517-
dc.descriptionSarkissian, Clio Der et al.-
dc.description.abstractPrzewalski’s horses (PHs, Equus ferus ssp. przewalskii) were discovered in the Asian steppes in the 1870s and represent the last remaining true wild horses. PHs became extinct in the wild in the 1960s but survived in captivity, thanks to major conservation efforts. The current population is still endangered, with just 2,109 individuals, one-quarter of which are in Chinese and Mongolian reintroduction reserves [1]. These horses descend from a founding population of 12 wild-caught PHs and possibly up to four domesticated individuals [2–4]. With a stocky build, an erect mane, and stripped and short legs, they are phenotypically and behaviorally distinct from domesticated horses (DHs, Equus caballus). Here, we sequenced the complete genomes of 11 PHs, representing all founding lineages, and five historical specimens dated to 1878–1929 CE, including the Holotype. These were compared to the hitherto-most-extensive genome dataset characterized for horses, comprising 21 new genomes. We found that loci showing the most genetic differentiation with DHs were enriched in genes involved in metabolism, cardiac disorders, muscle contraction, reproduction, behavior, and signaling pathways. We also show that DH and PH populations split ∼45,000 years ago and have remained connected by gene-flow thereafter. Finally, we monitor the genomic impact of ∼110 years of captivity, revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic alleles, ranging from non-detectable to as much as 31.1%. This, together with the identification of ancestry informative markers and corrections to the International Studbook, establishes a framework for evaluating the persistence of genetic variation in future reintroduced populations.es_ES
dc.description.sponsorshipThis work was supported by the Danish Council for Independent Research, Natural Sciences (FNU-4002-00152B); the Danish National Research Foundation (DNFR94); the Villum Fonden Blokstipendium (2014); the Lundbeck Foundation (R52-A5062); the Israel Science Foundation (1365/10); the German Research Council (DFG-LU852/7-4); the NIH (R01-GM40282); the Caesar Kleberg Foundation for Wildlife Conservation; the John and Beverly Stauffer Foundation; FP7 European Marie-Curie programs (CIG-293845, ITN-290344, IEF-328024, IEF-299176, and IEF-302617); a National Science Foundation Graduate Research Fellowship; and the Human Frontier Science Program (LT000320/2014).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/293845es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/290344es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/328024es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/299176es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/302617es_ES
dc.rightsclosedAccesses_ES
dc.titleEvolutionary Genomics and Conservation of the Endangered Przewalski’s Horsees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.cub.2015.08.032-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.cub.2015.08.032es_ES
dc.identifier.e-issn1879-0445-
dc.contributor.funderDanish Council for Independent Researches_ES
dc.contributor.funderDanish Natural Science Research Counciles_ES
dc.contributor.funderDanish National Research Foundationes_ES
dc.contributor.funderLundbeck Foundationes_ES
dc.contributor.funderIsrael Science Foundationes_ES
dc.contributor.funderGerman Research Foundationes_ES
dc.contributor.funderNational Institutes of Health (US)es_ES
dc.contributor.funderCaesar Kleberg Foundation for Wildlife Conservationes_ES
dc.contributor.funderJohn and Beverly Stauffer Foundationes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderNational Science Foundation (US)es_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001732es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003554es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003977es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001659es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000001es_ES
dc.identifier.pmid26412128-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeartículo-
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