Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/151121
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
DC FieldValueLanguage
dc.contributor.authorMotiño, Omar-
dc.contributor.authorAgra, Noelia-
dc.contributor.authorBrea, Rocío-
dc.contributor.authorDomínguez-Moreno, Marina-
dc.contributor.authorGarcía-Monzón, Carmelo-
dc.contributor.authorCarnovale, Cristina E.-
dc.contributor.authorBoscá, Lisardo-
dc.contributor.authorCasado, Marta-
dc.contributor.authorMayoral, Rafael-
dc.contributor.authorValdecantos, M. P.-
dc.contributor.authorValverde, Ángela M.-
dc.contributor.authorFrancés, Daniel E.-
dc.contributor.authorMartín-Sanz, Paloma-
dc.date.accessioned2017-06-09T08:47:53Z-
dc.date.available2017-06-09T08:47:53Z-
dc.date.issued2016-
dc.identifierdoi: 10.1016/j.bbadis.2016.06.009-
dc.identifierissn: 0925-4439-
dc.identifier.citationBBA - Molecular Basis of Disease 1862(9): 1710-1723 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/151121-
dc.description.abstractCyclooxygenase-2 (COX-2) is involved in different liver diseases but little is known about the significance of COX-2 in the development and progression of non-alcoholic steatohepatitis (NASH). This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of steatohepatitis and hepatic fibrosis. In the present work, hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were either fed methionine-and-choline deficient (MCD) diet to establish an experimental non-alcoholic steatohepatitis (NASH) model or injected with carbon tetrachloride (CCl) to induce liver fibrosis. In our animal model, hCOX-2-Tg mice fed MCD diet showed lower grades of steatosis, ballooning and inflammation than Wt mice, in part by reduced recruitment and infiltration of hepatic macrophages, with a corresponding decrease in serum levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tg mice showed a significant attenuation of the MCD diet-induced increase in oxidative stress and hepatic apoptosis observed in Wt mice. Even more, hCOX-2-Tg mice treated with CCl had significantly lower stages of fibrosis and less hepatic content of collagen, hydroxyproline and pro-fibrogenic markers than Wt controls. Collectively, our data indicates that constitutive hepatocyte COX-2 expression ameliorates NASH and liver fibrosis development in mice by reducing inflammation, oxidative stress and apoptosis and by modulating activation of hepatic stellate cells, respectively, suggesting a possible protective role for COX-2 induction in NASH/NAFLD progression.-
dc.description.sponsorshipThis work was supported by Financing Program for short stays abroad for Assistant Researchers (CONICET-Argentina) (2618/13) and ANPCyT-PICT2383-2012 to D.F.; SAF2012-39732 (MINECO, Spain) and CIBERehd (ISCIII, Spain) (CB06/04/1069) to M.C.; SAF2014-52492 (MINECO, Spain) to L.B.; S2010/BMD-2378 (Comunidad de Madrid, CAM) to L.B. and P.M.S.; RD12/0042/0019 (ISCIII, Spain) and CIBERehd (ISCIII, Spain) to L.B. and P.M.S.; SAF-2015-65267-R (MINECO/FEDER), S2010/BMD-2423 (Comunidad de Madrid, CAM), EFSD and Amylin Paul Langerhans Grant and CIBERdem (ISCIII, Spain) to A.M.V.; PI13/01299 (ISCIII, Spain) to C.G-M.; SAF2013-43713-R (MINECO, Spain) to P.M.S.-
dc.publisherElsevier-
dc.relationMINECO/ICTI2013-2016/SAF2014-52492-R-
dc.relationS2010/BMD-2378/CIFRA-
dc.relationMINECO/ICTI2013-2016/SAF2015-65267-R-
dc.relationMINECO/ICTI2013-2016/SAF2013-43713-R-
dc.relationS2010/BMD-2423/MOIR-
dc.rightsclosedAccess-
dc.subjectSteatohepatitis-
dc.subjectInflammation-
dc.subjectCOX-2-
dc.subjectFibrosis-
dc.subjectLiver-
dc.titleCyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice-
dc.typeartículo-
dc.identifier.doi10.1016/j.bbadis.2016.06.009-
dc.date.updated2017-06-09T08:47:54Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderPaul G. Allen Family Foundation-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderConsejo Nacional de Investigaciones Científicas y Técnicas (Argentina)-
dc.contributor.funderAgencia Nacional de Promoción Científica y Tecnológica (Argentina)-
dc.contributor.funderComunidad de Madrid-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000952es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002923es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003074es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeartículo-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
Appears in Collections:(IBV) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record

SCOPUSTM   
Citations

24
checked on May 27, 2022

WEB OF SCIENCETM
Citations

26
checked on May 24, 2022

Page view(s)

546
checked on May 27, 2022

Download(s)

114
checked on May 27, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.