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Generation of a human iPSC line from a patient with a defect of intergenomic communication

AuthorsZurita Díaz, Francisco; Galera, Teresa; González Páramos, Cristina; Moreno-Izquierdo, Ana; Schneiderat, Peter; Fraga, Mario F.; Fernández, Agustín F.; Garesse, Rafael CSIC ORCID; Gallardo, M. Esther CSIC ORCID
Issue Date2016
CitationStem Cell Research 16(1): 120-123 (2016)
AbstractHuman iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.
Publisher version (URL)https://doi.org/10.1016/j.scr.2015.12.016
Identifiersdoi: 10.1016/j.scr.2015.12.016
e-issn: 1876-7753
issn: 1873-5061
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