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http://hdl.handle.net/10261/151048
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rosal, Blanca del | - |
dc.contributor.author | Carrasco, Elisa | - |
dc.contributor.author | Sanz-Rodríguez, Francisco | - |
dc.contributor.author | Juarranz, Ángeles | - |
dc.contributor.author | Jaque, Daniel | - |
dc.date.accessioned | 2017-06-08T07:17:21Z | - |
dc.date.available | 2017-06-08T07:17:21Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1002/adfm.201601953 | - |
dc.identifier | e-issn: 1616-3028 | - |
dc.identifier | issn: 1616-301X | - |
dc.identifier.citation | Advanced Functional Materials 26(33): 6060-6068 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/151048 | - |
dc.description.abstract | Nowadays, one of the most exciting applications of nanotechnology in biomedicine is the development of localized, noninvasive therapies for diverse diseases, such as cancer. Among them, nanoparticle-based photothermal therapy (PTT), which destroys malignant cells by delivering heat upon optical excitation of nanoprobes injected into a living specimen, is emerging with great potential. Two main milestones that must be reached for PTT to become a viable clinical treatment are deep penetration of the triggering optical excitation and real-time accurate temperature monitoring of the ongoing therapy, which constitutes a critical factor to minimize collateral damage. In this work, a yet unexplored capability of near-infrared emitting semiconductor nanocrystals (quantum dots, QDs) is demonstrated. Temperature self-monitored QD-based PTT is presented for the first time using PbS/CdS/ZnS QDs emitting in the second biological window. These QDs are capable of acting, simultaneously, as photothermal agents (heaters) and high-resolution fluorescent thermal sensors, making it possible to achieve full control over the intratumoral temperature increment during PTT. The differences observed between intratumoral and surface temperatures in this comprehensive investigation, through different irradiation conditions, highlight the need for real-time control of the intratumoral temperature that allows for a dynamic adjustment of the treatment conditions in order to maximize the efficacy of the therapy. | - |
dc.description.sponsorship | This project was supported by the Spanish Ministerio de Economía y Competitividad under project and MAT2013-47395-C4-1-R. B.d.R. thanks Universidad Autónoma de Madrid for an FPI grant. F.R. acknowledges scholarship support from the Fonds de recherche du Québec—Nature et technologies (FRQNT) under the Programme de Bourses d’Excellence (Merit Scholarship Program for Foreign Students). A.B. is thankful to the Canadian Institutes of Health Research and the Breast Cancer Society of Canada (CIHR-BCSC), for postdoctoral funding granted to him through an Eileen Iwanicki Fellowship in Breast Cancer Imaging. F.V. is grateful to the Natural Sciences and Engineering Research Council (NSERC) of Canada, FRQNT, and the Canada Foundation for Innovation (CFI) for supporting his research program. F.V. also gratefully acknowledges the Fondation Sibylla Hesse. D.M. is grateful for the financial support from NSERC, FRQNT, CFI, and the Centre Québécois sur les Matériaux Fonctionnels (CQMF), Canada | - |
dc.publisher | Wiley-VCH | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2013-47395-C4-1-R | - |
dc.rights | closedAccess | - |
dc.subject | Quantum dots | - |
dc.subject | Nanothermometry | - |
dc.subject | Infrared imaging | - |
dc.subject | Photothermal therapy | - |
dc.title | Infrared-emitting QDs for thermal therapy with real-time subcutaneous temperature feedback | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1002/adfm.201601953 | - |
dc.date.updated | 2017-06-08T07:17:21Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Canadian Institutes of Health Research | - |
dc.contributor.funder | Breast Cancer Society of Canada | - |
dc.contributor.funder | Fonds de Recherche du Québec | - |
dc.contributor.funder | Universidad Autónoma de Madrid | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Natural Sciences and Engineering Research Council of Canada | - |
dc.contributor.funder | Fonds de Recherche Nature et Technologies (Canada) | - |
dc.contributor.funder | Canada Foundation for Innovation | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001805 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003151 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004593 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000024 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000038 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012172 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
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