English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/151031
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

IPSCs-based anti-aging therapies: Recent discoveries and future challenges

AuthorsPareja-Galeano, Helios; Sanchis-Gomar, Fabian; Pérez, Laura M.; Emanuele, Enzo; Lucia, Alejandro; Gálvez, Beatriz G.; Gallardo, M. Esther
KeywordsInduced pluripotent stem cells
Regenerative medicine
DOT1L
In vivo reprogramming
Sarcopenia
Issue Date2016
PublisherElsevier
CitationAgeing Research Reviews 27: 37-41 (2016)
AbstractThe main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition.
Publisher version (URL)https://doi.org/10.1016/j.arr.2016.02.007
URIhttp://hdl.handle.net/10261/151031
DOI10.1016/j.arr.2016.02.007
Identifiersdoi: 10.1016/j.arr.2016.02.007
e-issn: 1872-9649
issn: 1568-1637
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
ipscsbased.pdf423,26 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.