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| Título: | PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes |
Autor: | Anta, Begoña CSIC; Crespo, Piero CSIC ORCID; Serrador, Juan M. CSIC ORCID; Santos de Dios, Eugenio CSIC ORCID CVN ; Muñoz Terol, Alberto CSIC ORCID; Oliva, José Luis; Rojas, José M. | Fecha de publicación: | 2016 | Editor: | Nature Publishing Group | Citación: | Cell Death and Disease 7(7): e2311 (2016) | Resumen: | The cyclopentenone prostaglandin A(1) (PGA(1)) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA(1) triggers apoptosis by a process that entails the specific activation of H-and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA(1) treatment; in these cells, the cellular demise was rescued by overexpression of either H-Ras or N-Ras. Consistently, the mutant H-Ras-C118-S, defective for binding PGA(1), did not produce cell death. Molecular analysis revealed a key role for the RAF-MEK-ERK signaling pathway in the apoptotic process through the induction of calpain activity and caspase-12 cleavage. We propose that PGA(1) evokes a specific physiological cell death program, through H- and N-Ras, but not K-Ras, activation at endomembranes. Our results highlight a novel mechanism that may be of potential interest for tumor treatment. | Descripción: | B Anta et al. | Versión del editor: | https://doi.org/10.1038/cddis.2016.219 | URI: | http://hdl.handle.net/10261/150955 | DOI: | 10.1038/cddis.2016.219 | Identificadores: | doi: 10.1038/cddis.2016.219 issn: 2041-4889 |
| Aparece en las colecciones: | (CBM) Artículos (IBBTEC) Artículos (IIBM) Artículos (IBMCC) Artículos |
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| pgaendomembranes.pdf | 2,07 MB | Adobe PDF |  Visualizar/Abrir |
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