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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Montolio, Marisol | - |
dc.contributor.author | Messeguer, Joaquim | - |
dc.contributor.author | Masip, Isabel | - |
dc.contributor.author | Guijarro, Patricia | - |
dc.contributor.author | Gavin, Rosalina | - |
dc.contributor.author | Río, José Antonio del | - |
dc.contributor.author | Messeguer Peypoch, Ángel | - |
dc.contributor.author | Soriano, Eduardo | - |
dc.date.accessioned | 2009-07-20T10:12:37Z | - |
dc.date.available | 2009-07-20T10:12:37Z | - |
dc.date.issued | 2009-07-16 | - |
dc.identifier.citation | Chemistry and Biology (2009), doi: 10.1016/j.chembiol.2009.05.006 (In press) | en_US |
dc.identifier.issn | 1074-5521 | - |
dc.identifier.uri | http://hdl.handle.net/10261/15090 | - |
dc.description | 11 pages, 7 figures.-- Article in press. | en_US |
dc.description | Supporting information (Suppl. discussion, suppl. experimental procedures + suppl. fogis S1-S3, 5 pages) available at: http://dx.doi.org/10.1016/j.chembiol.2009.05.006 | - |
dc.description.abstract | Secreted semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. We screened a peptoid combinatorial library to search for semaphorin 3A inhibitors, and identified a peptoid (SICHI: semaphorin Induced chemorepulsion inhibitor) that blocks semaphorin 3A-chemorepulsion and growth-cone collapse in axons at millimolar concentrations. SICHI inhibits the binding of semaphorin 3A to its receptor complex (neuropilin 1/plexin A1) and semaphorin 3A-induced phosphorylation of GSK3. Chemorepulsion induced by semaphorin 3F or netrin 1 is not blocked by SICHI. We also show that SICHI promotes neural regeneration of damaged axons. We suggest that SICHI, a selective inhibitor of semaphorin 3A, is of therapeutic interest for approaches aimed at promoting axonal regeneration and brain repair. | en_US |
dc.description.sponsorship | This work was supported by grants from the Fundació Marató TV3 (2003-030831, to A.M.), from the Fundació Marató TV3 and Fundació Obra Social Caixa Catalunya (to E.S.), and from the Spanish Ministerio de Educación y Ciencia (CTQ2005-00995/BQU and SAF2008-0048, to A.M.; SAF2005-0171 and BFU2008-3980, to E.S.; and BFU2006-13651, to J.A.D.R.). | en_US |
dc.format.extent | 44821 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Semaphorin | en_US |
dc.subject | Axon guidance | en_US |
dc.subject | Semaphorin Induced Chemorepulsion Inhibitor (SICHI) | en_US |
dc.subject | Peripheral nervous system and central nervous system injury | en_US |
dc.title | A Semaphorin 3A Inhibitor Blocks Axonal Chemorepulsion and Enhances Axon Regeneration | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1016/j.chembiol.2009.05.006 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.chembiol.2009.05.006 | en_US |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Fichero | Descripción | Tamaño | Formato | |
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Semaphorin_Press_release.pdf | CSIC Press release (Spanish lang.) | 43,77 kB | Adobe PDF | Visualizar/Abrir |
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