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Targeting innate immunity with dsRNA-conjugated mesoporous silica nanoparticles promotes antitumor effects on breast cancer cells

AuthorsSancenón, Félix; Marcos, M. Dolores; Bernardo, A. R. CSIC; Martínez Máñez, Ramón; Jiménez Lara, Ana M. CSIC ORCID ; Murguía, José Ramón CSIC ORCID CVN
KeywordsAntitumor agents
Breast carcinoma
Mesoporous gated materials
Polyinosinic–polycytidylic acid
Drug delivery
Issue Date2016
CitationChemistry - A European Journal 22(5): 1582-1586 (2016)
AbstractWe describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK-BR-3 breast carcinoma cells. Our results show that poly(I:C)-conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA-TLR3 interaction. Such interaction also triggered apoptotic pathways in SK-BR-3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
Identifiersdoi: 10.1002/chem.201504629
e-issn: 1521-3765
issn: 0947-6539
Appears in Collections:(IIBM) Artículos

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