English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/150885
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Targeting innate immunity with dsRNA-conjugated mesoporous silica nanoparticles promotes antitumor effects on breast cancer cells

AuthorsSancenón, Félix; Marcos, M. Dolores; Bernardo, A. R. ; Martínez Máñez, Ramón; Jiménez Lara, Ana M. ; Murguía, José Ramón
KeywordsAntitumor agents
Breast carcinoma
Mesoporous gated materials
Polyinosinic–polycytidylic acid
Drug delivery
Issue Date2016
PublisherWiley-VCH
CitationChemistry - A European Journal 22(5): 1582-1586 (2016)
AbstractWe describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK-BR-3 breast carcinoma cells. Our results show that poly(I:C)-conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA-TLR3 interaction. Such interaction also triggered apoptotic pathways in SK-BR-3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
URIhttp://hdl.handle.net/10261/150885
DOI10.1002/chem.201504629
Identifiersdoi: 10.1002/chem.201504629
e-issn: 1521-3765
issn: 0947-6539
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.