English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150870
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes

AutorAdrados, Isabel; Larrasa-Alonso, J.; Galarreta, A.; López-Antona, I.; Menéndez, C.; Menéndez, Camino ; Abad, María; Moreno-Bueno, Gema ; Palmero, Ignacio
Fecha de publicación2016
EditorNature Publishing Group
CitaciónOncogene 35(27): 3485-3494 (2016)
ResumenCellular senescence is an antiproliferative response with essential functions in tumor suppression and tissue homeostasis. Here we show that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor of senescence. Our data show that SIX1 is specifically downregulated in fibroblasts upon oncogenic stress and other pro-senescence stimuli, as well as in senescent skin premalignant lesions. Silencing of SIX1 in human fibroblasts suffices to trigger senescence, which is mediated by p16INK4A and lacks a canonical senescence-associated secretory phenotype. Interestingly, SIX1-associated senescence is further characterized by the expression of a set of development and differentiation-related genes that significantly overlap with genes associated with SIX1 in organogenesis or human tumors, and show coincident regulation in oncogene-induced senescence. Mechanistically, we show that gene regulation by SIX1 during senescence is mediated, at least in part, by cooperation with Polycomb repressive complexes. In summary, our results identify SIX1, a key development regulator altered in human tumors, as a critical repressor of cellular senescence, providing a novel connection between senescence, differentiation and tumorigenesis.
URIhttp://hdl.handle.net/10261/150870
DOI10.1038/onc.2015.408
Identificadoresdoi: 10.1038/onc.2015.408
e-issn: 1476-5594
issn: 0950-9232
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.