English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150855
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

D1 but not D4 dopamine receptors are critical for MDMA-induced neurotoxicity in mice

AutorGranado, N.; Ares-Santos, Sara ; Moratalla, Rosario
Palabras claveParkinson’s disease
Drug addiction
Methcathinone
Striatum
TH
DAT
Amphetamine derivatives
Methamphetamine
Fecha de publicación2014
EditorTaylor & Francis
CitaciónNeurotoxicity Research 25: 100- 109 (2014)
ResumenMDMA, an addictive psychostimulant-consumed worldwide, has the ability to induce neurotoxic effects and addiction in laboratory animals and in humans through its effects on monoaminergic systems. MDMA-induced neurotoxicity in mice occurs primarily in dopaminergic neurons and does not significantly affect the serotonergic system. As the neurotoxic effects of MDMA in mice involve excessive dopamine (DA) release, DA receptors are highly likely to play a role in MDMA neurotoxicity, but the specific dopamine receptor subtypes involved have not previously been determined definitively. In this study, dopamine D1 and D4 receptor knock-out mice (D1R-/- and D4R-/-) were used to determine whether these receptors are involved in MDMA neurotoxicity. D1R inactivation attenuated MDMA-induced hyperthermia, decreased the reduction of dopamine and dopamine metabolite levels, and protected against dopamine terminal loss and reactive astrogliosis as determined in the striatum, 7 days after MDMA treatment. In sharp contrast, inactivation of D4R did not prevent hyperthermia or the neurotoxic effects of MDMA. Altogether, these results indicate that D1R, but not D4R, plays a significant role in the dopaminergic striatal neurotoxicity observed after exposure to MDMA. © 2013 Springer Science+Business Media New York.
URIhttp://hdl.handle.net/10261/150855
DOI10.1007/s12640-013-9438-8
Identificadoresdoi: 10.1007/s12640-013-9438-8
issn: 1029-8428
Aparece en las colecciones: (IC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.