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Título

NRF2 in neurodegenerative diseases

AutorCuadrado, Antonio
Palabras claveNeurodegenerative diseases
Proteinopathy
Neuroinflammation
Neuroprotection
Alzheimer's disease
Oxidative stress
Fecha de publicación2016
EditorElsevier
CitaciónCurrent Opinion in Toxicology 1: 46-53 (2016)
ResumenNeurodegenerative diseases, and degenerative disorders as a whole, share in common the deviation from homeostatic responses related to the control of proteostasis and low-grade chronic oxidative, inflammatory, and metabolic stress. These are all crucial events where transcription factor Nuclear factor (erythroid-derived 2)-like 2 (NRF2) plays a very important defensive role. In this paper, biochemical and genetic evidence connecting NRF2 with neurodegenerative diseases will be discussed, mainly in the context of preclinical mouse models and in patients with Alzheimer's and Parkinson's disease. NRF2 can be targeted pharmacologically and the most successful drugs to endorse a neuroprotective therapy will be commented, including dimethyl fumarate.
URIhttp://hdl.handle.net/10261/150821
DOI10.1016/j.cotox.2016.09.004
Identificadoresdoi: 10.1016/j.cotox.2016.09.004
issn: 2468-2020
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