English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150802
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

AutorPajares, Marta; Cuadrado, Antonio ; Rojo, Ana I.
Palabras claveNeurodegenerative diseases
Oxidative stress
Unfolded protein response
Fecha de publicación2017
CitaciónRedox Biology 11: 543-553 (2017)
ResumenNeurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance and folding of the proteome thanks to a wide network that integrates the regulation of signaling pathways, gene expression and protein degradation systems. This review attempts to summarize the most relevant findings about the transcriptional modulation of proteostasis exerted by the transcription factor NRF2 (nuclear factor (erythroid-derived 2)-like 2). NRF2 has been classically considered as the master regulator of the antioxidant cell response, although it is currently emerging as a key component of the transduction machinery to maintain proteostasis. As we will discuss, NRF2 could be envisioned as a hub that compiles emergency signals derived from misfolded protein accumulation in order to build a coordinated and perdurable transcriptional response. This is achieved by functions of NRF2 related to the control of genes involved in the maintenance of the endoplasmic reticulum physiology, the proteasome and autophagy.
Versión del editorhttps://doi.org/10.1016/j.redox.2017.01.006
Identificadoresdoi: 10.1016/j.redox.2017.01.006
issn: 2213-2317
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
neurodegenerativediseases.pdf811,57 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.