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Title

α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction

AuthorsJurado-Gómez, Jaime ; Navascués, Joaquín de ; Gorfinkiel, Nicole
KeywordsActomyosin
Morphogenesis
Vinculin
α-Catenin
DE-Cadherin
Oscillation
Apical contraction
Issue Date2-Nov-2016
PublisherCompany of Biologists
CitationJournal of Cell Science 129: 4496- 4508 (2016)
AbstractWe have investigated how cell contractility and adhesion are functionally integrated during epithelial morphogenesis. To this end, we have analysed the role of α-Catenin, a key molecule linking E-Cadherin-based adhesion and the actomyosin cytoskeleton, during Drosophila embryonic dorsal closure, by studying a newly developed allelic series. We find that α-Catenin regulates pulsatile apical contraction in the amnioserosa, the main force-generating tissue driving closure of the embryonic epidermis. α-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin, also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability. Furthermore, we uncover a genetic interaction between α-Catenin and Vinculin, and a tension-dependent recruitment of Vinculin to amniosersoa apical cell membranes, suggesting the existence of a mechano-sensitive module operating in this tissue.
URIhttp://hdl.handle.net/10261/150760
DOI10.1242/jcs.193268
Identifiersdoi: 10.1242/jcs.193268
issn: 1477-9137
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