Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/15073
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Title

Solving liquid chromatography mass spectrometry coelution problems in the analysis of environmental samples by multivariate curve resolution

AuthorsPeré-Trepat, Emma; Lacorte Bruguera, Silvia CSIC ORCID; Tauler, Romà
KeywordsMultivariate curve resolution
Alternating least squares
MCR-ALS
LC–MS
Coelutions
Short column
Fast chromatography
Biocides
Environmental samples
Issue Date17-May-2005
PublisherElsevier
CitationJournal of Chromatography A 1096(1-2): 111-122 (2005)
AbstractMultivariate curve resolution-alternating least squares (MCR-ALS) is shown to be a powerful tool to resolve coelution problems in liquid chromatograpy–mass spectrometry (LC–MS) in scan mode. This investigation was performed using two types of LC columns, one traditional LC column of 25 cm length with a slow gradient and a shorter LC column of 7.5 cm with a rapid gradient which allowed much faster analysis and save of reagents and solvents. Mixtures of multiple biocide compounds were simultaneously analyzed in standard mixtures and in environmental samples (sediment and wastewater samples) with little sample pretreatment. Using the more traditional LC 25 cm column, all biocide compounds were properly resolved by MCR-ALS and quantitatively analyzed with estimated errors always below 20%. When fast chromatography (LC column of 7.5 cm) was used, MCR-ALS resolution of the more strongly coeluted compounds was also achieved but limitations were found in their simultaneous quantitative determination, specially for environmental samples.
Description12 pages, 7 figures.-- PMID: 16301074 [PubMed].-- Printed version published Nov 25, 2005.-- Issue title: "Chemical Separations and Chemometrics".
Publisher version (URL)http://dx.doi.org/10.1016/j.chroma.2005.04.089
URIhttp://hdl.handle.net/10261/15073
DOI10.1016/j.chroma.2005.04.089
ISSN0021-9673
E-ISSN1873-3778
Appears in Collections:(IDAEA) Artículos

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