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Adherence to a Mediterranean diet influences the fecal metabolic profile of microbial-derived phenolics in a Spanish cohort of middle-age and older people

AuthorsGutiérrez-Díaz, Isabel; Fernández-Navarro, Tania; Salazar, Nuria CSIC ORCID; Bartolomé, Begoña CSIC ORCID ; Moreno-Arribas, M. Victoria CSIC ORCID ; González de los Reyes-Gavilán, Clara CSIC ORCID ; Gueimonde Fernández, Miguel CSIC ORCID ; González Solares, Sonia
KeywordsFecal metabolites excretion
Physical activity
Phenolic compounds
Mediterranean dietary pattern
Issue Date2017
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 65(3): 586-595 (2017)
AbstractDespite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. In this study, the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS/MS in 74 volunteers. This fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic acids being the major classes of phenolic metabolites excreted in feces. Subjects with higher adherence to a Mediterranean dietary pattern presented greater fecal concentrations of benzoic and 3-hydroxyphenylacetic acids, positively correlated with the intake of the principal classes and subclasses of polyphenols and fibers, and higher levels of Clostridium cluster XVIa and Faecalibacterium prausnitzii. These results provide a link among the Mediterranean dietary pattern, the bioactive compounds of the diet, and the fecal metabolic phenolic profile.
Identifiersdoi: 10.1021/acs.jafc.6b04408
e-issn: 1520-5118
issn: 0021-8561
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