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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lozano-Ojalvo, Daniel | - |
dc.contributor.author | Molina, Elena | - |
dc.contributor.author | López-Fandiño, Rosina | - |
dc.date.accessioned | 2017-05-26T07:42:33Z | - |
dc.date.available | 2017-05-26T07:42:33Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1371/journal.pone.0151813 | - |
dc.identifier | e-issn: 1932-6203 | - |
dc.identifier.citation | PLoS ONE 11(3): e0151813 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/150464 | - |
dc.description.abstract | The anti-allergic potential of egg white protein hydrolysates (from ovalbumin, lysozyme and ovomucoid) was evaluated as their ability to hinder cytokine and IgE production by Th2-skewed human peripheral blood mononuclear cells (PBMCs), as well as the release of proinflammatory factors and generation of reactive oxygen species from Th1-stimulated peripheral blood leukocytes (PBLs). The binding to IgE of egg allergic patients was determined and the peptides present in the hydrolysates were identified. The hydrolysates with alcalase down-regulated the production of Th2-biased cytokines and the secretion of IgE to the culture media of Th2-skewed PBMCs, and they significantly neutralized oxidative stress in PBLs. The hydrolysates of ovalbumin and ovomucoid with pepsin helped to re-establish the Th1/Th2 balance in Th2-biased PBMCs, while they also inhibited the release of pro-inflammatory mediators and reduced oxidative stress in PBLs treated with inflammatory stimuli. The hydrolysates with alcalase, in addition to equilibrating Th2 differentiation, exhibited a low IgE-binding. Therefore, they would elicit mild allergic reactions while retaining T cellstimulating abilities, which might correlate with an anti-allergic benefit. | - |
dc.description.sponsorship | Financial support was received from the project AGL2014-59771-R from Ministerio de Economía y Competitividad (MINECO, Spain). DL-O is recipient of a FPU fellowship from Ministerio de Educación, Cultura y Deporte (MECD, Spain). | - |
dc.publisher | Public Library of Science | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-59771-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Regulation of exacerbated immune responses in human peripheral blood cells by hydrolysed egg white proteins | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1371/journal.pone.0151813 | - |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0151813 | - |
dc.date.updated | 2017-05-26T07:42:33Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.pmid | 27007699 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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HumanPeripheralBlood.pdf | 1,68 MB | Adobe PDF | Visualizar/Abrir |
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