English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150421
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Tyrosine hydroxylase haploinsufficiency prevents age-associated arterial pressure elevation and increases half-life in mice

Otros títulosArterial pressure benefits in heterozygous TH mice
AutorGamella-Pozuelo, Luis; Grande, M. Teresa; Clemente-Lorenzo, Milagros; Murillo-Gómez, Cayetana; Pablo, Flora de ; López-Novoa, José M.; Hernández-Sánchez, Catalina
Palabras claveChatecolamines
Tyrosine hydroxylase
Hypertension
Stress
Life-span
Fecha de publicaciónene-2017
EditorElsevier
CitaciónBiochim Biophys Acta.1863(1):113-120 (2017)
ResumenCatecholamines are essential for the maintenance of physiological homeostasis under basal and stress conditions. We aim to determine the impact of deletion of a single allele of the tyrosine hydroxylase(Th) gene might have on aging arterial pressure and life-span. We found that Th haploinsufficiency prevents age associated increase of arterial pressure (AP) in mature adult mice, and it results in the extension of the half-life of TH-heterozygous (HET) mice respect to their wild-type (WT) littermates.Heart performance was similar in both genotypes. To further investigate the lack of increase in AP with age in TH-HET mice, we measured the AP response to intra-peritoneal administration of substances involved in AP regulation. The response to acetylcholine and the basal sympathetic tone were similar in both genotypes, while norepinephrine had a greater pressor effect in TH-HET mice,which correlated with altered adrenoreceptor expression in blood vessels and the heart. Furthermore,sympatho-adrenomedular response to stress was attenuated in TH-HET mice. Plasma catecholamine levels and urine glucose increased markedly in WT but not in TH-HET mice after stress. Our results showed that TH-HET mice are resistant to age-associated hypertension, present a reduction in the sympathetic response to stress and display an extended half-life.
Descripción28 p.-5 fig.
Versión del editorhttp://dx.doi.org/10.1016/j.bbadis.2016.10.014
URIhttp://hdl.handle.net/10261/150421
DOI10.1016/j.bbadis.2016.10.014
ISSN0006-3002
Aparece en las colecciones: (CIB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Gamella-Pozuelo L-BBADIS-2017.pdfPostprint329,33 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.