English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150367
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

The homeobox gene Distal-less induces ventral appendage development in Drosophila

AutorGorfinkiel, Nicole ; Morata, Ginés ; Guerrero Vega, Isabel
Palabras claveDistal-less
Dorsal-to-ventral limb transformation
Drosophila distal appendages
Vestigial
Fecha de publicación24-jul-1997
EditorCold Spring Harbor Laboratory. Press
CitaciónGenes and Development 11: 2259- 2271 (1997)
ResumenThis study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila. Lack of Dll function causes a change in the identity of ventral appendage cells (legs and antennae) that often results in the loss of the appendage. Ectopic Dll expression in the proximal region of ventral appendages induces nonautonomous duplication of legs and antennae by the activation of wingless and decapentaplegic. Ectopic Dll expression in dorsal appendages produces transformation into corresponding ventral appendages; wings and halteres develop ectopic legs and the head-eye region develops ectopic antennae. In the wing, the exogenous Dll product induces this transformation by activating the endogenous Dll gene and repressing the wing determinant gene vestigial. It is proposed that Dll induces the development of ventral appendages and also participates in a genetic address that specifies the identity of ventral appendages and discriminates the dorsal versus the ventral appendages in the adult. However, unlike other homeotic genes, Dll expression and function is not defined by a cell lineage border. Dll also performs a secondary and late function required for the normal patterning of the wing.
URIhttp://hdl.handle.net/10261/150367
Identificadoresissn: 0890-9369
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
MorataG_TheHomeoboxGene.pdf451,75 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.