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Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators

AutorAcaz-Fonseca, E.; Sanchez-Gonzalez, R.; Azcoitia, I.; Arévalo, María Ángeles ; García-Segura, Luis M.
Palabras claveReactive astrocytes
Neurotrophic factors
Neuroinflammation
Neuroglobin
Brain edema
Glutamate transporters
Fecha de publicación2014
CitaciónMolecular and Cellular Endocrinology 389: 48- 57 (2014)
ResumenNeuroprotective actions of 17β-estradiol (estradiol) are in part mediated by direct actions on neurons. Astrocytes, which play an essential role in the maintenance of the homeostasis of neural tissue, express estrogen receptors and are also involved in the neuroprotective actions of estradiol in the brain. Estradiol controls gliosis and regulates neuroinflammation, edema and glutamate transport acting on astrocytes. In addition, the hormone regulates the release of neurotrophic factors and other neuroprotective molecules by astrocytes. In addition, reactive astrocytes are a local source of neuroprotective estradiol for the injured brain. Since estradiol therapy is not free from peripheral risks, alternatives for the hormone have been explored. Some selective estrogen receptor modulators (SERMs), which are already in use in clinical practice for the treatment of breast cancer, osteoporosis or menopausal symptoms, exert similar actions to estradiol on astrocytes. Therefore, SERMs represent therapeutic alternatives to estradiol for the activation of astroglia-mediated neuroprotective mechanisms. © 2014 Elsevier Ireland Ltd.
URIhttp://hdl.handle.net/10261/150261
DOI10.1016/j.mce.2014.01.009
Identificadoresdoi: 10.1016/j.mce.2014.01.009
issn: 1872-8057
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