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Título

Patterning function of homothorax/extradenticle in the thorax of Drosophila

AutorAldaz, Silvia ; Morata, Ginés ; Azpiazu, Natalia
Palabras clavehth
eyg
Notum patterning
exd
Fecha de publicación16-nov-2004
EditorCompany of Biologists
CitaciónDevelopment 132: 439- 446 (2005)
ResumenIn Drosophila, the morphological diversity is generated by the activation of different sets of active developmental regulatory genes in the different body subdomains. Here, we have investigated the role of the homothorax/extradenticle (hth/exd) gene pair in the elaboration of the pattern of the anterior mesothorax (notum). These two genes are active in the same regions and behave as a single functional unit. We find that their original uniform expression in the notum is downregulated during development and becomes restricted to two distinct, α and β subdomains. This modulation appears to be important for the formation of distinct patterns in the two subdomains. The regulation of hth/exd expression is achieved by the combined repressing functions of the Pax gene eyegone (eyg) and of the Dpp pathway. hth/exd is repressed in the body regions where eyg is active and that also contain high levels of Dpp activity. We also present evidence for a molecular interaction between the Hth and the Eyg proteins that may be important for the patterning of the α subdomain.
URIhttp://hdl.handle.net/10261/150234
DOI10.1242/dev.01585
Identificadoresdoi: 10.1242/dev.01585
issn: 0950-1991
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