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Vasopressin stimulates inositol phospholipid metabolism in rat medulla oblongata in vivo

AutorMoratalla, Rosario ; Vallejo, M.; Lightman, S. L.
Palabras claveNucleus tractus solitarii
Vasopressin receptor
Brain-phosphoinositide
Arg- vasopressin
Fecha de publicación1988
EditorElsevier
CitaciónBrain Research 450: 398- 402 (1988)
ResumenWe have investigated whether microinjections of arginine-vasopressin (AVP) into the nucleus tractus solitarii (NTS) of rats results in the stimulation of inositol phospholipid metabolism, a biochemical event related to the activation of V1-type receptors. We found that AVP, but not the related peptides oxytocin or deamino-D-AVP, increases the incorporation of [3H]myoinositol into lipids and the accumulation of labelled inositol phosphates in the dorsomedial medulla oblongata of lithium-treated rats. These effects were abolished by local pretreatment with D-(CH2)5-Tyr(Me)-AVP, a specific antagonist of V1-receptors. It is concluded that the effects of AVP in the NTS of rats are likely to be due to an action on specific receptors (V1-like) and subsequent activation of polyphosphoinositide turnover
URIhttp://hdl.handle.net/10261/150192
Identificadoresissn: 0006-8993
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