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Title

Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals

AuthorsFitó, Montserrat; Torres, Carlos F. ; Vázquez de Frutos, Luis ; Reglero, Guillermo ; Covas, María Isabel
KeywordsVascular endothelial growth factor
Complement 3
Alkylglycerols
Obesity
Inflammation
Complement 4
Issue Date2016
PublisherSpringer
CitationInflammopharmacology 24(2): 127-131 (2016)
AbstractAlkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.
URIhttp://hdl.handle.net/10261/150126
DOI10.1007/s10787-016-0265-4
Identifiersdoi: 10.1007/s10787-016-0265-4
e-issn: 1568-5608
issn: 0925-4692
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