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Water-soluble compounds from Lentinula edodes influencing the HMG-CoA reductase activity and the expression of genes involved in the cholesterol metabolism

AutorGil-Ramírez, Alicia ; Caz, Víctor; Martín-Hernández, Roberto; Marin, Francisco R. ; Reglero, Guillermo ; Soler-Rivas, Cristina
Palabras claveLow-density array
Cholesterol
Polysaccharides
Shiitake
HMG-CoA reductase
Eritadenine
Fecha de publicación2016
EditorAmerican Chemical Society
CitaciónJournal of Agricultural and Food Chemistry 64(9): 1910-1920 (2016)
ResumenA water extract from Lentinula edodes (LWE) showed HMG-CoA reductase inhibitory activity but contained no statins. NMR indicated the presence of water-soluble α- and β-glucans and fucomannogalactans. Fractions containing derivatives of these polysaccharides with molecular weight down to approximately 1 kDa still retained their inhibitory activity. Once digested LWE was applied to Caco2 in transport experiments, no significant effect was noticed on the modulation of cholesterol-related gene expression. But, when the lower compartment of the Caco2 monolayer was applied to HepG2, some genes were modulated (after 24 h). LWE was also administrated to normo- and hypercholesterolemic mice, and no significant lowering of serum cholesterol levels was observed; but reduction of triglycerides in liver was observed. However, LWE supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin, suggesting that it could hold potential as a hypolipidemic/hypocholesterolemic extract, although further dose-dependent studies should be carried out.
URIhttp://hdl.handle.net/10261/150047
DOI10.1021/acs.jafc.5b05571
Identificadoresdoi: 10.1021/acs.jafc.5b05571
e-issn: 1520-5118
issn: 0021-8561
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