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The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

AutorQuiñones, Mar ; Margalef, Maria; Arola-Arnal, Anna; Muguerza, B.; Miguel, Marta ; Aleixandre, Amaya
Fecha de publicación2015
EditorRoyal Society of Chemistry (Great Britain)
CitaciónFood and Function 6(11): 3479-3489 (2015)
ResumenWe studied the short-term antihypertensive effect of flavan-3-ols (-)-epicatechin, (+)-catechin and (-)-catechin, in spontaneously hypertensive rats (SHR). Plasma metabolites and the corresponding plasma antioxidant capacity were determined. All the assayed flavan-3-ols decreased systolic blood pressure (SBP) in SHR. Their antihypertensive effects were less pronounced than that of Captopril (50 mg kg) and were not shown in normotensive Wistar-Kyoto rats. 6 mg kg (-)-epicatechin caused the maximum decrease in SBP. The maximum effects of the catechin monomers were observed post-administration of 0.5 mg kg of flavan-3-ols, (-)-catechin being the least effective among the three assayed compounds. Glucuronide and methyl glucuronide metabolites were obtained in the flavan-3-ol treated SHR, but it was not possible to relate the antihypertensive effect of the assayed flavan-3-ols with a concrete plasma metabolite or with their antioxidant effect. In conclusion, the studied flavan-3-ols could be responsible for the antihypertensive effect of cocoa products.
Versión del editorhttps://doi.org/10.1039/c5fo00547g
URIhttp://hdl.handle.net/10261/149996
DOI10.1039/c5fo00547g
Identificadoresdoi: 10.1039/c5fo00547g
e-issn: 2042-650X
issn: 2042-6496
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