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Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells

AutorValdés, Alberto ; Sullini, G.; Ibáñez, Elena ; Cifuentes, Alejandro ; García-Cañas, Virginia
Palabras claveTranscriptomics
Colon cancer
Foodomics
Rosemary
Unfolded protein response
Carnosic acid
Fecha de publicación2015
EditorElsevier
CitaciónJournal of Functional Foods 15: 429-439 (2015)
ResumenSeveral studies have demonstrated that rosemary polyphenols exert changes in the lipid metabolism in adipose and hepatic cells. In this work, the effects of a polyphenol-enriched supercritical rosemary extract (SC-RE) and carnosic acid (CA) on the transcriptome and cholesterol metabolism in HT-29 colon cancer cells were examined using a Foodomics approach. Targeted metabolomics analysis indicated that the SC-RE treatment induced cholesterol accumulation after 24 h. Transcriptomic analysis suggested that most of the changes induced by the SC-RE and CA were orchestrated by unfolded protein response (UPR) and triggered by endoplasmic reticulum stress. Results suggested up-regulation of VLDLR gene as the principal contributor to the observed cholesterol accumulation in SC-RE-treated cells. In addition, the SC-RE attenuated the activity of E2F transcription factor, down-regulating several genes involved in G1-S transition of the cell cycle.
URIhttp://hdl.handle.net/10261/149960
DOI10.1016/j.jff.2015.03.043
Identificadoresdoi: 10.1016/j.jff.2015.03.043
issn: 1756-4646
e-issn: 2214-9414
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