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dc.contributor.authorChavan, Rahul Dilipes_ES
dc.contributor.authorShinde, Pramodes_ES
dc.contributor.authorGirkar, Kaustubhes_ES
dc.contributor.authorMadage, Rajendraes_ES
dc.contributor.authorChowdhary, Abhayes_ES
dc.identifier.citationPharmacognosy Research 8(2): 105-111 (2016)es_ES
dc.description.abstract[Background] Human influenza is a seasonal disease associated with significant morbidity and mortality. Anti-flu ayurvedic/herbal medicines have played a significant role in fighting the virus pandemic. Plumbagin and allicin are commonly used ingredients in many therapeutic remedies, either alone or in conjunction with other natural substances. Evidence suggests that these extracts are associated with a variety of pharmacological activities.es_ES
dc.description.abstract[Objective] To evaluate anti-influenza activity from Plumbago indica and Allium sativum extract against Influenza A (H1N1)pdm09.es_ES
dc.description.abstract[Materials and Methods] Different extraction procedures were used to isolate the active ingredient in the solvent system, and quantitative HPLTC confirms the presence of plumbagin and allicin. The cytotoxicity was carried out on Madin-Darby Canine kidney cells, and the 50% cytotoxic concentration (CC50) values were below 20 mg/mL for both plant extracts. To assess the anti-influenza activity, two assays were employed, simultaneous and posttreatment assay.es_ES
dc.description.abstract[Results] A. sativum methanolic and ethanolic extracts showed only 14% reduction in hemagglutination in contrast to P. indica which exhibited 100% reduction in both simultaneous and posttreatment assay at concentrations of 10 mg/mL, 5 mg/mL, and 1 mg/mL.es_ES
dc.description.abstract[Conclusions] Our results suggest that P. indica extracts are good candidates for anti-influenza therapy and should be used in medical treatment after further research.es_ES
dc.description.sponsorshipThe study was funded by Intra-mural fund of Haffkine Institute for Training, Research and Testing, Mumbai, India.es_ES
dc.publisherMedknow Publicationses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectAllium sativumes_ES
dc.subjectAnti-influenza activityes_ES
dc.subjectPlumbago indicaes_ES
dc.titleAssessment of Anti-Influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extractses_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderHaffkine Institutees_ES
oprm.item.hasRevisionno ko 0 false*
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