English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/14988
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 81 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children

AutorSunyer, Jordi; Torrent, Maties; Muñoz-Ortiz, Laura; Ribas-Fitó, Núria; Carrizo, Daniel; Grimalt, Joan O.; Antó, Josep M.; Cullinan, Paul
Palabras claveAsthma
Atopy
Children
Dichlorodiphenyldichloroethylene (DDE)
Organochlorine
Fecha de publicación18-jul-2005
EditorNational Institute of Environmental Health Sciences (U.S.)
CitaciónEnvironmental Health Perspectives 113(12): 1787-1790 (2006)
ResumenPrevalence of asthma increases with increasing dichlorodiphenyldichloroethylene (DDE) levels. However, the effect of early-life exposure, the fundamental window of exposure, is unknown. We assessed the association between prenatal DDE and other organochlorine compounds, and atopy and asthma during infancy. All women presenting for antenatal care in Menorca (Spain) over 12 months starting in mid-1997 were invited to take part in a longitudinal study; 482 children were subsequently enrolled, and 468 (97.1%) provided complete outcome data up to the fourth year of study. Prenatal exposure of organochlorine compounds was measured in cord serum in 405 (83%) children. Asthma was defined on the basis of wheezing at 4 years of age, persistent wheezing, or doctor-diagnosed asthma. We measured specific immunoglobulin-E (IgE) against house dust mite, cat, and grass in sera extracted at 4 years of age. DDE (median = 1.03 ng/mL) was detected in all children, as well as hexachlorobenzene (0.68 ng/mL) and polychlorobiphenyls (0.69 ng/mL). Wheezing at 4 years of age increased with DDE concentration, particularly at the highest quartile [9% in the lowest quartile (< 0.57 ng/mL) vs. 19% in the highest quartile (1.90 ng/mL); relative risk = 2.63 (95% confidence interval 1.19–4.69), adjusting for maternal asthma, breast-feeding, education, social class, or other organochlorines]. The association was not modified by IgE sensitization and occurred with the same strength among nonatopic subjects and among those with persistent wheezing or diagnosed asthma. DDE was not associated with atopy alone. Prenatal exposure to DDE residues may contribute to development of asthma.
Descripción4 pages.-- PMID: 16330365 [PubMed].-- Printed version published Dec 2005.
Versión del editorhttp://dx.doi.org/10.1289/ehp.8127
URIhttp://hdl.handle.net/10261/14988
DOI10.1289/ehp.8127
ISSN0091-6765 (Print)
1552-9924 (Online)
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Art_1.pdf108,96 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.