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Drugs on clinical development for the treatment of amyotrophic lateral sclerosis

AutorMartínez, Ana ; Palomo Ruiz, Valle; Pérez, Daniel I.; Gil, Carmen
Palabras claveALS
New drugs
Clinical trials
Cell therapy
Fecha de publicaciónabr-2017
EditorTaylor & Francis
CitaciónExpert Opin Investig Drugs. 26(4):403-414 (2017)
ResumenIntroduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron progressive disorder for which no treatment exists up to date. However, there are some investigational drugs and therapies under clinical development that may offer some hope in the near future
Areas covered: We have revised all the ALS ongoing clinical trials (until November 2016) and collected in Clinical.trials.gov or EudraCT. We have described them in a comprehensive way and grouped them in the following sections: biomarkers, biological therapies, cell therapy, drug repurposing and new drugs.
Expert Opinion: Despite the multiple obstacles that explain the absence of effective drugs for the treatment of ALS, joint efforts among patient’s associations, public and private sectors have fueled innovative research in the field, resulting in several compounds that are in the late stages of clinical trials. Drug repositioning is also playing an important role, having achieved the approval of some orphan drug applications, in late phases of clinical development. Endaravone has been recently approved in Japan and is pending in USA.
Descripción30 p.-3 fig.-3 tab.
Versión del editorhttp://dx.doi.org/10.1080/13543784.2017.1302426
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