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Formation and characterization of model cell membranes and their interaction with Magnetic Nanoparticles

AuthorsRuiz Rincón, Silvia
AdvisorFuente, Jesús M. de la
Issue Date2015
PublisherUniversidad de Zaragoza
AbstractUnderstanding the process occurred in cell membranes as well as their interaction with external agents such as Magnetic Nanoparticles (MNPs) is a goal of main importance in biomedicine. In this work model cell membranes of a mixture of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol were transferred onto mica substrates by Langmuir-Blodgett technique (LB) to mimic a real cell membrane. The high quality and chemical structure of the monolayers formed were confirmed by means of Atomic Force Microscopy (AFM) imaging and Contact Angle measurements. Due to the amphiphilic features of the compounds used in this work, a study of the stability of the monolayer in liquid media was carried out observing as the monolayer re-assembled into bilayer. This behaviour was explained by means of Force Spectroscopy (FS) studies with a noticeable increase in the breakthrough force values. Furthermore, the deposition of MNPs onto monolayer was carried out by LB in a successful way obtaining a well-covered distribution of MNPs with the final purpose of study the membrane response when it is exposed to alternating magnetic fields.
DescriptionProyecto Final del Máster Universitario en Materiales Nanoestructurados para Aplicaciones Nanotecnológicas, Departamento de Química Física de la Universidad de Zaragoza.
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