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Osteoblast Cell Response on the Ti6Al4V Alloy Heat-Treated

AuthorsChávez-Díaz, Mercedes Paulina; Escudero Rincón, María Lorenza; Arce-Estrada, Elsa Miriam; Cabrera-Sierra, Román
Issue Date23-Apr-2017
PublisherMultidisciplinary Digital Publishing Institute
CitationMaterials 10 (4): 445 (2017)
AbstractIn an effort to examine the effect of the microstructural changes of the Ti6Al4V alloy, two heat treatments were carried out below (Ti6Al4V<sub>800</sub>) and above (Ti6Al4V<sub>1050</sub>) its β-phase transformation temperature. After each treatment, globular and lamellar microstructures were obtained. Saos-2 pre-osteoblast human osteosarcoma cells were seeded onto Ti6Al4V alloy disks and immersed in cell culture for 7 days. Electrochemical assays in situ were performed using OCP and EIS measurements. Impedance data show a passive behavior for the three Ti6Al4V alloys; additionally, enhanced impedance values were recorded for Ti6Al4V<sub>800</sub> and Ti6Al4V<sub>1050</sub> alloys. This passive behavior in culture medium is mostly due to the formation of TiO<sub>2</sub> during their sterilization. Biocompatibility and cell adhesion were characterized using the SEM technique; Ti6Al4V as received and Ti6Al4V<sub>800</sub> alloys exhibited polygonal and elongated morphology, whereas Ti6Al4V<sub>1050</sub> alloy displayed a spherical morphology. Ti and O elements were identified by EDX analysis due to the TiO<sub>2</sub> and signals of C, N and O, related to the formation of organic compounds from extracellular matrix. These results suggest that cell adhesion is more likely to occur on TiO<sub>2</sub> formed in discrete α-phase regions (hcp) depending on its microstructure (grains).
Publisher version (URL)https://doi.org/10.3390/ma10040445
Identifiersdoi: 10.3390/ma10040445
Appears in Collections:(CENIM) Artículos
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