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Direct substitution of alcohols in pure water by Brønsted acid catalysis

AuthorsOrtiz, Rosa; Herrera, Raquel P.
Issue Date1-Apr-2017
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 22(4): 574 (2017)
AbstractWith the increasing concern for sustainability, the use of environmentally friendly media to perform chemical processes has attracted the attention of many research groups. Among them, the use of water, as the unique solvent for reactions, is currently an active area of research. One process of particular interest is the direct nucleophilic substitution of an alcohol avoiding its preliminary transformation into a good leaving group, since one of the by-products in this approach would be water. The direct substitution of allylic, benzylic, and tertiary alcohols has been achieved through S<sub>N</sub>1-type reactions with catalytic amounts of Brønsted or Lewis acids; however, organic solvents are often required. In this review, the pioneering S<sub>N</sub>1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed.
Publisher version (URL)https://doi.org/10.3390/molecules22040574
Appears in Collections:(ISQCH) Artículos
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