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Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

AuthorsDgachi, Youssef; Bautista-Aguilera, Óscar M.; Benchekroun, M.; Martin, Hélène; Bonet, Alexandre; Knez, Damijan; Godyń, Justyna; Malawska, Bárbara; Gobec, Stanislav; Chioua, Mourad ; Janockova, Jana; Soukup, O.; Chabchoub, Fakher; Marco-Contelles, José ; Ismaili, L.
Issue Date14-May-2016
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 21 (5): 634 (2016)
AbstractWe report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound <b>3Bb</b> displayed a mixed-type inhibition of human acetylcholinesterase (IC<sub>50</sub> = 1.28 ± 0.03 μM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.
Publisher version (URL)http://doi.org/10.3390/molecules21050634
Identifiersdoi: 10.3390/molecules21050634
Appears in Collections:(IQOG) Artículos
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